BDBM11646 (2S,3S)-2-amino-3-(3-phenyl-1,2,4-oxadiazol-5-yl)-1-(pyrrolidin-1-yl)butan-1-one::alpha-amino acid pyrrolidide 8::oxadiazole based amide
SMILES: C[C@@H]([C@H](N)C(=O)N1CCCC1)c1nc(no1)-c1ccccc1
InChI Key: InChIKey=PCDUMSZJKQYNPZ-AAEUAGOBSA-N
Data: 4 IC50
PDB links: 1 PDB ID contains this monomer as substructures. 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dipeptidyl peptidase 4 (Homo sapiens (Human)) | BDBM11646 ((2S,3S)-2-amino-3-(3-phenyl-1,2,4-oxadiazol-5-yl)-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.97E+4 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Merck Research Laboratories | Assay Description The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m... | Bioorg Med Chem Lett 16: 5373-7 (2006) Article DOI: 10.1016/j.bmcl.2006.07.061 BindingDB Entry DOI: 10.7270/Q2JD4V0K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 9 (Homo sapiens (Human)) | BDBM11646 ((2S,3S)-2-amino-3-(3-phenyl-1,2,4-oxadiazol-5-yl)-...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m... | Bioorg Med Chem Lett 16: 5373-7 (2006) Article DOI: 10.1016/j.bmcl.2006.07.061 BindingDB Entry DOI: 10.7270/Q2JD4V0K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase VIII (Homo sapiens (Human)) | BDBM11646 ((2S,3S)-2-amino-3-(3-phenyl-1,2,4-oxadiazol-5-yl)-...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m... | Bioorg Med Chem Lett 16: 5373-7 (2006) Article DOI: 10.1016/j.bmcl.2006.07.061 BindingDB Entry DOI: 10.7270/Q2JD4V0K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 2 (DPP II) (Homo sapiens (Human)) | BDBM11646 ((2S,3S)-2-amino-3-(3-phenyl-1,2,4-oxadiazol-5-yl)-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m... | Bioorg Med Chem Lett 16: 5373-7 (2006) Article DOI: 10.1016/j.bmcl.2006.07.061 BindingDB Entry DOI: 10.7270/Q2JD4V0K | |||||||||||
More data for this Ligand-Target Pair |